Greg Maddux, who won four Cy Young Awards and 355 games, will announce his retirement Monday.
Maddux will hold a news conference at baseball's winter meetings in his hometown of Las Vegas, according to a statement from his agent, Scott Boras.
Maddux, 42, closed out his career with the Dodgers. He did not start in the playoffs and made his final appearance in the National League Championship Series, mopping up for Chad Billingsley in the game in which the Philadelphia Phillies eliminated the Dodgers.
Maddux said that day he was not offended by serving as a mop-up man.
"It was a privilege," he said. "I felt privileged to do it. I was glad I had a chance to pitch.
"It stinks that we lost. But there's a lot of good young players here, and they're only going to get better. I think this team has a chance to be good for a while."
Maddux, a nine-time All-Star while pitching for the Atlanta Braves and Chicago Cubs, started his major-league career in 1986. His 355 victories rank eighth in major league history, one more than Roger Clemens, with Maddux earning his final win by holding the San Francisco Giants to one run over six innings on Sept. 27.
The Dodgers acquired him from the San Diego Padres in August -- the second time in three years the Dodgers traded for him to fortify their rotation in a pennant stretch -- and he was 2-4 with a 5.09 earned-run average in seven starts.
Every 300-game winner eligible for the Hall of Fame has been inducted, with Maddux, Clemens and Tom Glavine not yet eligible.
Maddux also won his 18th Gold Glove this year.