2000: Barry Sanders retires a week before the season begins.
2001: Eddie George loses the Divisional Playoffs for the Tennessee Titans
2002: Daunte Culpepper throws 23 interceptions and breaks the record for fumbles in a season. The Vikings went 5-11.
2003: Marshall Faulk never has another 1000-yard rushing season for the rest of his career, and slowly declined in production. Played 21 of 33 games during the 2002 and 2003 seasons.
2004: Michael Vick breaks leg in the preseason, missing the entire season, and the Falcons went 5-11.
2005: Ray Lewis is injured his wrist in Week 15 and had his only season without an interception.
2006: Donovan McNabb tears his ACL, and meniscus, as well as a sports hernia and the Eagles miss the playoffs.
2007: Shaun Alexander sufferes a foot injury and misses six games. Production declines and he is no longer a Seahawk by 2009, and out of the League in 2010.
2008: Vince Young's production declines and he suffers long-term injuries the next season, as well as being benched for off-the-field reasons and never plays 16 games for the Titans.
2009: Brett Favre suffers an arm injury that severely hurts his performance and the Jets are eliminated from playoff contention after starting the first half of the season.
2010: Troy Polomalu sprains his MCL and misses the first four games of the season, and then hurts his PCL and misses even more games afterwards. Larry Fitzgerald is unable to participate in the Pro Bowl due to injury, but has a career year.
2011: Drew Brees plays an entire season, but throws twice as many interceptions, his QB Rating drops 20 points from the Super Bowl-winning season the year previous, and is part of the only team to lose in the playoffs to a team with a losing record; the 7-9 Seahawks. It is later revealed that Drew Brees played 6 weeks with a torn MCL.
2012: Peyton Hillis misses five games due to injury, and re-injures himself in Week 9 of the season. His rushing yards are cut in half after a breakout season the year before and he is cut from the team at the end of the season.
So it seems like Larry Fitzgerald has already broken it. No worries.
This house, is clean.