If they were unconstitutional, then seccession might be the right move, although it would not be peaceful under any circumstances.
The basic flaw in it though is that the vast majority of people don't understand the constitution well enough to determine if something is or is not constutional. Take taxes for example. As Justice Roberts said, congress has the right to require individuals to pay taxes. There is no serious legal opposition to that right. Yet we still see some individuals contest the government's right to collect taxes.
and you are correct in that the vast majority of americans haven't even given the constitution a once over, much less a dedicated study. you'll notice i did not mention a protest against the colletion of taxes, but of how those taxes are misappropriated by constitutional standards.
as an aside, i noted that justice roberts did not address that issue while adding his own context regarding constitutional bases for collecting said taxes.
so, the original assertion stands. if the populace had changed to the point of seeking secession peacefully on constitutional grounds, would an order of force by the commander in chef compel you to fire on said secessionists?