I just can't get around that huge clunky controller. The Wii was a gimmick but a fun gimmick, I just don't see this being that popular. From what I've seen it's an overpriced 360 with less games and a gimmick controller. Nintendo should really just stick to the handheld market and work on making some actually interesting games for those instead of a metric fug ton of kiddie poo that no one is interested in.
The controller is not really clunky at all. I have no problems holding it with my left hand and using the stylus with my right and I've not seen anymore gaming fatigue after multiple hours playing than I would with the 360 or PS3. It won't be replacing my 360 but the first-party and exclusive titles have been fun so far. It probably will become my go to streaming media device because of the controller though.