I don't think we match up well against the 49ers. Colin K is a mobile QB who can evade the pass rush (which let's face it didn't look great against the Falcons and got 1 sack when we all expected them to get 4 or 5). They have a powerful and experienced running back in Gore who gets better as the game goes on. They have a decent O-line and a solid opportunistic D.
They are the best team we will have faced this season so far (since week 1). We are traveling through 3 time zones to a stadium we haven't played in in years.
We do pretty well against the run, but that is against teams that usually have to abandon the run in the second half because they are down by 15 points. SF will likely not be in that position and will pound the rock for 4 quarters. They have a great TE who can help them in possession and can be dynamic down the field. If we miss tackles, V. Davis will eat us alive.
I don't see this game shaping up as a win. I wouldn't put a dime on any Panthers game because that is some serious bad juju. But for those out there saying we win the match-ups in this game...I don't see it and I don't think we will keep this game within a touchdown. Sorry.