I commonly use my own statistical formula to predict game scores for sports betting. It has proven to be remarkably accurate and I almost don't want to share it, but here we go.
In order to determine the final score of the game I take each teams points scored against the opponent, and subtract it from the points scored on average for each opponent.
The Panthers currently hold teams on average 7.575 points below their average for the season. The 49ers currently hold teams 2.825 points below their average for the season. If we subtract these scores from each teams average points scored for the season Panthers (25.5) and 49ers (27.3), we should have a relatively accurate prediction of the outcome.
Statistically we win this game 22.675 to 19.725
Sadly, the difference in the scores falls within 1SD (approx 7 points) of each other, so the prediction is pretty useless. But, it does show that we are slightly favored.