Most of the major cities that everyone has been saying are great with one exception. I'd take a pass on Miami.. I've never found it extremely enjoyable or American. A good portion of the people are Caribbean island immigrants or homeless people.
Can't speak on western cities but for the East I'd do New Orleans, DC, NY, Boston, and a Charlotte to Ashville Trip for NC (little over 2hr drive).
that is exactly why I said Miami.